Tell individuals that a home teaspoon just isn't an accurate measuring device and these use could lead on to overdosage and critical adverse reactions [see OVERDOSAGE (ten)]. For prescriptions wherever a measuring device is just not delivered, a pharmacist can provide an ideal calibrated measuring machine and can provide Guidance for measuring the right dose.

Carcinogenicity scientific tests have been conducted with codeine. Two-calendar year studies in F344/N rats and B6C3F1 mice were carried out to evaluate the carcinogenic possible of codeine. No proof of tumorigenicity was observed in male and feminine rats at codeine dietary doses as many as 70 and eighty mg/kg/day (somewhere around equivalent to fifteen and 20 occasions, the MRHD on a mg/m2 basis, respectively).

Some Negative effects may perhaps manifest that sometimes tend not to will need medical attention. These Unwanted effects may disappear through treatment method as Your system adjusts to the drugs. Also, your well being treatment Specialist could possibly tell you about methods to forestall or minimize Some side effects.

talk to your medical doctor with regards to the Secure use of Liquor while you're taking this medication. Alcohol will make the Uncomfortable side effects of promethazine worse.

The concomitant usage of Promethazine with Codeine Oral Alternative with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may possibly bring about a rise in codeine plasma concentrations and also a lessen in Energetic metabolite morphine plasma concentration which could result in an analgesic efficacy reduction or signs or symptoms of opioid withdrawal.

To reduce your danger, your medical doctor must have you take the smallest dose that actually works, and take it for your shortest doable time. See also The best way to Use area For more info about dependancy.

When you are having this medicine, it is particularly important that your healthcare Experienced know When you are getting any on the medicines mentioned under. The next interactions are selected on The idea of their potential significance and are not necessarily all-inclusive.

Bronchial asthma and Other Pulmonary Disease Using Promethazine with Codeine Oral Option in people with acute or severe bronchial bronchial asthma in an unmonitored location or while in the absence of resuscitative equipment is contraindicated [see Contraindications (four)]. Opioid analgesics and antitussives, which includes codeine, one of several active ingredients in Promethazine with Codeine Oral Alternative, should not be Employed in sufferers with acute febrile disease related to productive cough or in individuals with Serious respiratory disorder in which interference with capability to obvious the tracheobronchial tree of secretions would have a deleterious effect on the patient's respiratory functionality.

Even though significant heterogeneity exists relating to CYP2D6 enzyme capability within all ethnicities, Hispanic and White sufferers exhibit the highest CYP2D6 "ultrafast metabolizer" functionality.[21]

If this SPL contains inactivated NDCs listed through the FDA initiated compliance motion, they will be specified as a result.

Tell your physician Should your cough lasts, returns, or will get even worse after seven times or if it is accompanied by headache that doesn't go away, fever, significant sore throat, or rash.

Codeine Codeine is undoubtedly an opioid agonist reasonably selective for your mu-opioid receptor, but using a A lot weaker affinity than morphine. The analgesic and antitussive properties of codeine are already speculated to come from its conversion to morphine.

In case you are getting promethazine liquid, usually do not use a residence spoon to measure your dose. Utilize the measuring spoon or cup that came Along with the medication or utilize a spoon made specifically for measuring medication.

The causal role of opioids in the medical syndrome of hypogonadism is unknown as the numerous health-related, physical, lifestyle, and psychological stressors that will Promethazine codeine syrup influence gonadal hormone concentrations have not been adequately managed for in reports performed up to now [see ADVERSE REACTIONS (six)].